Formación continua/ Ciencias/ B122

Workshop: Cellullar Sensors

Dr. Emily Liman: University of Southern California, Los Angeles, USA

Dr. Félix Viana: Instituto de Neurociencias de Alicante- Universidad Miguel Hernández-CSIC, Alicante, Spain

finalizado

Centro de Atención al Estudiante

Desde: 29 Octubre 2024
Hasta: 31 Octubre 2024
Presencial
Sede Antonio Machado de Baeza

Investigadora
Inglés

20 Horas
400 euros

How we sense the environment, including our internal state, is a fundamental question in Biology. It is crucial for understanding human physiology but also helps explain the detection of signals by insects spreading deadly diseases like malaria or dengue. Despite important advances in this field in the last years, many critical questions remain. This workshop brings together eminent scientists from across the world who have a shared interest in sensory signaling, from structural biology to translating basic science into therapeutic approaches. Speakers will discuss recent advances including the structures of sensory ion channels and receptors, the discovery and role of sensory receptors in physiology and disease, signaling in the neuroimmune interface and the development of new methods and molecular sensors. Finally, we will discuss the pathophysiology of cellular sensors in relation to various diseases, including pain, and the restoration of sensory functions. Our aim is to discuss advances in cellular sensors from a range of model organisms, analyzed at different levels of complexity, from the molecular dissection of their function to the design and implementation of artificial sensors for controlled drug release. The workshop should be attractive to researchers working in a range of fields, including neuroscience, immunology, physiology, biophysics, chemical biology and bioengineering.

WORKSHOP CELLULAR SENSOR new

Plan de estudio y calendario
Profesorado

Plan de estudios

Monday, 28th October 2024

18:00 Registration

20:30 Get together cocktail Cafeteria of the Sede Antonio Machado UNIA. Palacio de Jabalquinto

Tuesday, 29th October 2024

8:15 Breakfast at cafeteria UNIA

8:45 Welcome address by the organizers: E. Liman and F. Viana

Session I: Structure and function of nociceptive channels
Chair: Félix Viana
9:00 Vera Moiseenkova-Bell, University of Pennsylvania, Philadelphia, USA
Structural Pharmacology of TRPV Channels
9:30 Guillaume Sandoz, Institute of Biology Valrose (iBV), Nice, France
Cellular sensing with two-pore domain potassium channels
10:00 Ute Hellmich, University of Jena, Jena, Germany
TRP channels on a leash - structural dynamics and regulation through their intrinsically disordered regions
10:30–11:30 Coffee break and poster session
Session II: Chemosensation
Chair: Claire Wyart
11:30 Emily Liman, University of Southern California, Los Angeles, USA
pH monitoring in taste cells by OTOP proton channels
12:00 Elena Onancea, Brown University, Providence, USA
Cellular sensors for melanosomal pH
12:30 Vanessa Ruta, The Rockefeller University, New York, USA
Sensing scents: structural insights into odor detection
13:00 José López Barneo, University of Sevilla, Sevilla, Spain
Mitochondrial acute oxygen sensing and signaling

13:30–15:00 Lunch at Hotel Puerta de la Luna

Session III: Mechanobiology
Chair: Vera Moiseenkova-Bell
15:00 Alexander Chesler, NIH/NCCIH, Bethesda, USA
Molecules and cells for touch and pain
15:30 Sergio Sarrio, Institute of Neurosciences UMH-CSIC, Alicante, Spain
PIEZO1 and PIEZO2 Blade domains are differently required for channel localization and functions
16:00 Jorge Fernández-Trillo, Institute of Neurosciences UMH-CSIC, Alicante, Spain
Mechanical sensitivity in MRGPRD nociceptors is mediated by Piezo2
16:15 Maria Giustina Rotordam, Nanion Technologies, Munich, Germany
Exploring the role of Piezo1 in the function and development of red blood cells using high-throughput patch clamp
16:30 Houcheng Wang, Imperial College London, United Kingdom
Modulation of calcium handling by β2AR signalling and PDE4s activity under mechanical stretch
16:45–17:15 Coffee break at cafeteria UNIA
Session IV: Sensory Circuits
Chair: Luke Lavis
17:15 Tobias Moser, University Medical Center, Göttingen, Germany
Synaptic processing of sensory information
17:45 Claire Wyart Paris Brain Institute, Paris, France
Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS

20:30 Dinner at Hotel Puerta de la Luna

Wednesday, 30th October 2024

8:15 Breakfast at cafeteria UNIA

Session V: Making and Implementing Novel Cellular Sensors
Chair: Elena Onancea
9:00 Luke Lavis, Janelia, Virginia, USA
Building brighter fluorophores for advanced imaging and sensing
9:30 Amadeu Llebaria, IQAC, Barcelona, Spain
Photopharmacology: using light for a precise control of drug action
10:00 Simon Wiegert, University of Heidelberg, Mannheim, Germany
All lights on the brain: tools for optical investigations of neuronal circuits
10:30 Don Arnold, University of Southern California, Los Angeles, USA
ATLAS: A rationally designed anterograde transsynaptic tracer
11:00 Maria Teresa Alonso, University of Valladolid, Valladolid, Spain
Direct measurements of luminal Ca2+ in endo-lysosomes with a novel Ca2+ sensor based on GFP-aequorin
11:30–12:15 Coffee and poster viewing
Session VI: The neuroimmune interface
Chair: Emily Liman
12:15 Henrique Veiga-Fernandes, Champalimaud Foundation, Lisbon, Portugal
Neuroimmune ecosystems
12:45 Aleksandra Deczkowska, Pasteur Institute, Paris, France
Immune-brain communication at the choroid plexus

13:15–14:45 . Lunch at Hotel Puerta de la Luna

Session VII: Ion channels and thermosensation
Chair: Emily Liman
14:45 Peter Zygmunt, Lund University, Malmö, Sweden
Intrinsic thermo- and mechanosensitive properties of human TRPA1
15:15 Jan Siemens, Heidelberg University, Heidelberg, Germany
A heat acclimation-induced neuronal pacemaker that drives heat tolerance
15:45 Marion Bied, Institute of Biology Valrose (iBV), Nice, France
UV-A Activation of Two Pore Domain Potassium Channels

16:00 Laura Primicheru, King’s College, London, United Kingdom
The analgesic mechanism of Palmitoylethanolamide
16:30 Guided Tour of Baeza (Sponsored by NANION)

20:30 Dinner at Hotel Puerta de la Luna

Thursday 31st October 2024

8:15 Breakfast at cafeteria UNIA

Session VII: Cellular Sensors in Disease States
Chair: Tobias Moser
9:00 Félix Viana, Institute of Neurosciences UMH-CSIC, Alicante, Spain Pathophysiology of mammalian thermosensitive TRP channels
9:30 Eva María Villalba-Riquelme, IDIBE, UMH, Elche, Alicante, Spain Nociceptive channels in chemotherapy-induced peripheral neuropathy: insights from paclitaxel and oxaliplatin in vitro preclinical models
9:45 Angela Lamberti, IDIBE, UMH, Elche, Alicante, Spain Thermo TRP ion channels as a key molecular and functional landmark for neuropathic pain transduction in subsets of somatosensory neurons
10:00 Charlotte Guhl, University of Jena, Jena, Germany
Endolysosomal channels in health and disease: from molecules to mechanisms

15 Concluding Remarks by the organizers: E. Liman and F. Viana

11:30 Bus Departure to Madrid Airport
Dr. Emily Liman: University of Southern California, Los Angeles, USA

Dr. Félix Viana: Instituto de Neurociencias de Alicante- Universidad Miguel Hernández-CSIC, Alicante, Spain
Don Arnold, University of Southern California, Los Angeles, USA
Alexander Chesler, NIH/NCCIH, Bethesda, USA
Aleksandra Deczkowska, Pasteur Institute, Paris, France
Simon Wiegert, University of Heidelberg, Mannheim, Germany
Luke Lavis, Janelia, Virginia, USA
Emily Liman, University of Southern California, Los Angeles, USA
José López Barneo, University of Sevilla, Sevilla, Spain
Amadeu Llebaria, Institute of Advance Chemistry of Catalonia, Barcelona, Spain
Vera Moiseenkova-Bell, University of Pennsylvania, Philadelphia, USA
Tobias Moser, University Medical Center, Göttingen, Germany
Elena Onancea, Brown University, Providence, USA
Vanessa Ruta, The Rockefeller University, New York, USA
Guilllaume Sandoz, Institute of Biology Valrose (iBV), Nice, France
Henrique Veiga-Fernandes, Champalimaud Foundation, Lisbon, Portugal
Félix Viana, Instituto de Neurociencias, UMH-CSIC, San Juan de Alicante, Spain
Claire Wyart, Paris Brain Institute, Paris, France

Orientación académica y profesional

Criterios de admisión

The aim of the workshop is to provide an integrated view of our current understanding of different cellular sensors and their biological relevance. The workshop should be attractive to researchers and students working in different fields (chemical biology, biophysics, bioengineering, immunology, neuroscience) and using different model systems. "See application guidelines"

GENERAL INFORMATION

FORMATE OF THE WORKSHOP:

The workshop will bring together 15 speakers and a maximum of 35 participants. The scientific programme will start on Tuesday 29th October in the morning and will end on Thursday 31th October in the morning. Ample time for informal discussion will be reserved. Participants will be invited to present a poster. Some abstracts will be selected for a short presentation.

VENUE OF THE WORKSHOP:

The workshop will be held in Baeza, at the “Antonio Machado Headquarters”, a XVII century building turned into a Conference Centre of the International University of Andalusia (UNIA). A complex made up of two historic buildings: the Jabalquinto Palace (XV/XVI centuries) and the old Seminary (XVII century) located in the heart of the historic complex, among the old University, church of Santa Cruz, the cathedral and the Upper Town Halls.
This site includes a recently restored residence, where speakers and participants will be accommodated. This same space is where the meetings will be held, which facilitates social interaction and informal discussions.
Baeza is a world historic heritage town, renowned for its Renaissance and Gothic buildings.

ACCOMMODATION

ACCOMMODATION:

We recommend all participants to stay in the University Residence, which is located in the same space where the Meetings will take place, to facilitate social interaction and informal discussions.

The accommodation in the University Residence is in shared double rooms, as there are not single rooms: €20/day. To make the reservation and the corresponding payment you must be previously registered for the workshop and then contact: Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo..

APPLICATION GUIDELINES

WORKSHOP REGISTRATION:

A) Applicants must complete an application form and submit it, along with:

A brief C.V.
A summary of the current research work of the candidate.

In case of presenting a poster, a summary of the poster of no more than one page, with the title, authorship, research center/institution/university, address and a summary of the communication.

See section "presentation of panels and posters”.

SEE LINK TO:
Application form (odt)
Application form (doc)*:

En cumplimiento del Reglamento General de Protección de Datos (Reglamento (UE) 2016/679), se le informa que los datos personales que se puedan recopilar se incorporarán y procesarán en algunos de los archivos de la Universidad Internacional de Andalucía (UNIA); los datos pueden divulgarse según lo previsto por la ley.
La autoridad responsable de los datos es: UNIA: Secretaría General (Secretario General). C / Américo Vespucio nº 2, Isla de la Cartuja. 41092 - SEVILLA, ESPAÑA.

Puede ejercer sus derechos de acceso, rectificación, eliminación y oposición contactando por escrito con la dirección mencionada anteriormente, a la atención del Delegado de Protección de Datos, o enviando un correo electrónico a Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo., o dirigiéndose al Servicio al Cliente de cualquiera de las sedes de la UNIA. Su derecho fundamental a la protección de datos.

B) Send the completed Application Form (doc/odt) and the attached documents as separate text files and in a single email message, to Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo., no later than 7 October 2024.

Selected applicants (with or without poster) will be notified directly. From that moment on, they must pay the corresponding registration fees*.

WORKSHOP FEES 2024:

Registration: 400,00 € (breakfast, lunch, coffe-breaks and dinner included)
Payment method: bank transfer to ‘La Caixa’
IBAN (international bank account number): ES78 21009166752200074348
SWIFT (BIC): CAIXESBBXXX

Registration fees deadline 11 October 2024
Selected applicants must indicate their full name and code number (it will appear in the webpage) in the bank transfer. After completing your payment by bank transfer, a proof of payment must be sent to: Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo..

The bank charges generated by the bank transfer will be paid by the applicants/attendees.

WORKSHOP panels/posters guidelines:

The scheduled dates for the presentation of panels/posters are:

A. Deadline to present the complete panels in digital format 11 OCTOBER 2024.

Presentation of the proposal: through the registration form in the Worhshop.

Shipping address for panels/posters: Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.

o For the oral presentation of posters it is essential to have formalized registration and payment of the Workshop.
o The co-director of the Workshop will indicate and assign the session in which to present the work.
o The organization will certify the effective presentation of each panel/poster during the Workshop.
o Each author individually or collectively may present a maximum of 2 panels.
o Researchers may display their panel in the campus facilities. To do this, they must bring their work printed in DIN A0 vertical format (84.1 x 118.9 cm) and arrange it in the provided fastening systems.

Panel/poster contents:

• Title: Arial bold 14 points.
• Subtitle (if applicable).
• Authorship (individual or collective).
• Keywords: maximum 4.
• Presentation / Summary of content: 120 words.
• Methodology: 100 words.
• Description and contents: through text and graphics.
• Conclusions: maximum 100 words
• Sources and essential bibliography.
• Format: to transfer digitally DIN A4; PDF. Type: Arial. Body: minimum 9 and maximum 12 points.

Entidades colaboradoras

The sponsorships of collaborating entities include academic fees for a limited number of participants. Those interested must contact the sponsors by presenting a brief C.V and a brief communication at the following address Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.

Entidades patrocinadoras

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